Biotechnologij\u0173 bendrov\u0117 \u201eALLOX\u201c pritrauk\u0117 apie 10 mln. eur\u0173 pradiniame finansavimo etape, kad i\u0161pl\u0117st\u0173 vaist\u0173 atradimo platform\u0105 ir paspartint\u0173 vidines mokslini\u0173 tyrim\u0173 programas. Finansavimo etapui vadovavo \u201eAsabys\u201c per fond\u0105 Sabadell Asabys II, prisid\u0117jo CDTI per SICC Innvierte ir Institut Catal\u00e0 de Finances.<\/p>\n
Bendrov\u0117 kuria platform\u0105, kuri sujungia didelio pralaidumo genetik\u0105, eksperimentin\u0119 biologij\u0105 ir DI metodus. Tikslas ai\u0161kus: grei\u010diau aptikti iki \u0161iol menkai i\u0161tirtas galimybes kurti ma\u017eos molekul\u0117s vaistus, kai tradiciniai metodai stringa.<\/p>\n
Vaist\u0173 paie\u0161ka da\u017enai sud\u0117tinga d\u0117l vadinam\u0173j\u0173 sunkiai paveikiam\u0173 taikini\u0173, ypa\u010d baltym\u0173 tarpusavio s\u0105veik\u0173 ir transkripcijos faktori\u0173, kuriems sunku rasti veiksming\u0173 ma\u017e\u0173 molekuli\u0173. \u201eALLOX\u201c siekia \u0161i\u0105 problem\u0105 spr\u0119sti identifikuodama baltymuose reguliacines sritis, kurios gal\u0117t\u0173 tapti nauj\u0173 gydym\u0173 taikiniais.<\/p>\n
Platforma vienu metu \u012fvertina t\u016bkstan\u010di\u0173 genetini\u0173 mutacij\u0173 poveik\u012f ir taip sudaro baltymo sri\u010di\u0173 \u017eem\u0117lap\u012f: kurios vietos lemia baltymo sulankstym\u0105, stabilum\u0105 ir s\u0105veikas. Tai padeda rasti galimus alosterinius ir ortosterinius taikinius bei kitas reguliacines vietas, \u012fskaitant potencialias prisijungimo ki\u0161enes, kuriose ateityje gal\u0117t\u0173 \u201e\u012fsitaisyti\u201c ma\u017eos molekul\u0117s vaistas.<\/p>\n
\u201eSujungdami didelio masto funkcinius duomenis su prognozuojan\u010diais DI modeliais, siekiame atverti daug platesn\u012f sud\u0117ting\u0173 vaist\u0173 taikini\u0173 spektr\u0105 ir pagreitinti i\u0161skirtini\u0173 ma\u017eos molekul\u0117s vaist\u0173 atradim\u0105\u201c, \u2013 sak\u0117 \u201eALLOX\u201c vadov\u0117 ir bendra\u012fk\u016br\u0117ja J\u00falia Domingo.<\/p>\n
Kartu su finansavimo naujiena bendrov\u0117 paskelb\u0117 paskyrusi Morten\u0105 Graugaard\u0105 nepriklausomu valdybos pirmininku. Jis turi daugiau nei 20 met\u0173 patirties gyvyb\u0117s moksl\u0173 investicij\u0173, mokslini\u0173 tyrim\u0173 ir pl\u0117tros bei verslo vystymo srityse, anks\u010diau \u0117jo vadovaujan\u010dias pareigas \u201eOrbis Medicines\u201c, \u201eNovo Holdings\u201c ir \u201eLundbeck\u201c.<\/p>\n
\u201eSvarbiausia, kad \u201eALLOX\u201c u\u017epildo kritin\u0119 duomen\u0173 sprag\u0105, kuri leid\u017eia kurti funkcionalias molekules, o ne vien identifikuoti prisijungian\u010dius junginius\u201c, \u2013 sak\u0117 Morten Graugaard.<\/p>\n
Gautos l\u0117\u0161os bus nukreiptos platformos paj\u0117gumams didinti, DI modeliams tobulinti ir vidinei vaist\u0173 paie\u0161kos komandai stiprinti. Bendrov\u0117 taip pat planuoja kelias tyrim\u0173 kryptis priartinti prie nuosavo ma\u017eos molekul\u0117s kandidat\u0173 portfelio ir aktyviau ie\u0161koti bendradarbiavimo su farmacijos bei biotechnologij\u0173 partneriais.<\/p>\n","protected":false},"excerpt":{"rendered":"
\u201eALLOX\u201c pritrauk\u0117 apie 10 mln. eur\u0173 ir pl\u0117s DI paremt\u0105 platform\u0105, skirt\u0105 rasti sud\u0117tingus vaist\u0173 taikinius ir spartinti ma\u017eos molekul\u0117s terapij\u0173 k\u016brim\u0105.<\/p>\n","protected":false},"author":0,"featured_media":66989,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[7],"tags":[51598,4093,102,83,51600,450,51599],"miestas":[],"class_list":["post-66986","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technologijos","tag-allox","tag-biotechnologijos","tag-dirbtinis-intelektas","tag-fintech","tag-mazos-molekules-vaistai","tag-rizikos-kapitalas","tag-vaistu-atradimas"],"acf":[],"_links":{"self":[{"href":"https:\/\/cp.snarskis.lt\/index.php\/wp-json\/wp\/v2\/posts\/66986","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cp.snarskis.lt\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cp.snarskis.lt\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/cp.snarskis.lt\/index.php\/wp-json\/wp\/v2\/comments?post=66986"}],"version-history":[{"count":0,"href":"https:\/\/cp.snarskis.lt\/index.php\/wp-json\/wp\/v2\/posts\/66986\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cp.snarskis.lt\/index.php\/wp-json\/wp\/v2\/media\/66989"}],"wp:attachment":[{"href":"https:\/\/cp.snarskis.lt\/index.php\/wp-json\/wp\/v2\/media?parent=66986"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cp.snarskis.lt\/index.php\/wp-json\/wp\/v2\/categories?post=66986"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cp.snarskis.lt\/index.php\/wp-json\/wp\/v2\/tags?post=66986"},{"taxonomy":"miestas","embeddable":true,"href":"https:\/\/cp.snarskis.lt\/index.php\/wp-json\/wp\/v2\/miestas?post=66986"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}